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Incoming cystine is subsequently converted to cysteine, which serves as a substrate for GSH synthesis ( As a member of the glutathione peroxidase family, GPX4 is the first identified core suppressor of ferroptosis ( Figure 2 )

Additionally, the excessive metabolism of iron can accelerate this process, ultimately leading to ferroptosis in RPECs (169)

Additionally, as a functional ligand of multiple receptors including LDLR, LDL receptor-related protein (LRP) and heparan sulfate proteoglycans (HSPG), Apo E facilitates the clearance of TRL particles, especially VLDL, VLDL and CM remnant particles, and regulates plasma cholesterol and TG levels 13,57

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